As many as __ of patients treated with a biologic disease-modifying antirheumatic drug experience a suboptimal response either initially or over time.(1)
C.) As many as 40% of patients treated with a TNF inhibitor experience a suboptimal response either initially or over time.(1) Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov. 2017;16(12):843-862.
Click the ‘Continue’ button to learn about approved and emerging JAK inhibitor treatment options that may help RA patients achieve and sustain complete remissions.
Elena M. Massarotti, MD
Associate Professor of Medicine
Harvard Medical School
Director of Clinical Lupus Trials, Division of Rheumatology
Vice Chair of Clinical Affairs, Department of Medicine
Brigham and Women's Hospital
William F.C. Rigby, MD
Vice Chairman, Academic Affairs
Department of Medicine
Professor of Medicine, Microbiology, and Immunology
Director, Rheumatology Research
Dartmouth Geisel School of Medicine
Amy Burdette, PhD
Manager, Educational Strategy & Content
Rebecca L. Julian, MS, ELS
Senior Manager, Editorial
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Upon completion, participants should be able to:
- Describe the clinical rationale for the modulation of JAK signaling as a therapeutic target in RA
- Apply information about the anticipated agent-specific clinical properties of various JAK inhibitors to individualized treatment decisions as these therapies become available
This activity is intended for rheumatologists.
Statement of Need
Despite a broad selection of approved treatments for rheumatoid arthritis (RA), most patients with this condition do not experience a complete, long-term response with currently available therapies. In an effort to more consistently achieve and sustain complete remissions, ongoing investigation has shifted focus to intracellular mediators of inflammation, such as the JAK family—a leading target of over 50 cytokines used in the JAK pathway to transduce intracellular signals. As such, targeting the JAK family is a rational therapeutic approach with potentially broad applications. Agents that have a broad JAK inhibition are now available for patients with RA, and the safety profiles of these treatments are largely predictable based on the biological functions of the targeted JAK isoforms. Novel agents with narrow JAK inhibition are also being investigated to address unmet treatment needs for this patient population. Soon clinicians may have additional JAK inhibitors in the RA armamentarium to select among when developing individualized treatment plans for patients with RA.
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This CME activity consists of a 1.0-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: December 17, 2018
Expiration Date: December 16, 2019
Estimated Time to Complete This Activity: 1 hour
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Elena M. Massarotti, MD
Consulting fees/advisory boards: Regeneron Pharmaceuticals, Inc., Sanofi-aventis U.S. Inc.
Contracted research: Sanofi-aventis U.S. Inc.
William F.C. Rigby, MD
Consulting fees/advisory boards: AbbVie, Inc., Bristol Myers-Squibb, F. Hoffman La-Roche, Pfizer, Inc.
Fees received for promotional/non-CME activities: Bristol Myers-Squibb
The writer, peer reviewers, and activity planners have no financial relationships to disclose.
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