A New Era in TGCT Treatment: Novel Targeted Therapies and Their Effect on Shared Decision Making
William D. Tap, MD
Chief, Sarcoma Medical Oncology Service
Memorial Sloan Kettering Cancer Center
New York, NY
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Rebecca L. Julian, MS, ELS
Senior Manager, Editorial
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Upon completion, participants should be able to:
- Describe the mechanisms of action, efficacy, and safety of emerging therapies in clinical development for TGCT
- Select appropriate treatment strategies for patients with TGCT, including in the context of clinical trial enrollment, based on recent clinical evidence, expert perspectives, and patient preferences
This activity is intended for medical oncologists, surgeons, and rheumatologists.
Statement of Need
TGCT is a rare, local, aggressive, heterogeneous, benign tumor associated with joint destruction, inflammation, pain, and swelling, which can result in significant impairment to physical function and have a profound effect on patients’ quality of life. It has an estimated annual incidence of 11 to 50 cases per 1 million individuals. Until recently, the current standard of care for TGCT was surgical resection of the tumor; however, not every person is a candidate for surgery. Research has shown that TGCT cells overexpress colony-stimulating factor 1 (CSF1), which leads to the recruitment of CSF1 receptor (CSF1R)-positive tumor-associated macrophages and drives tumor growth and progression. This finding has led to the development of CSF1R inhibitors. Clinicians need to be aware of the clinical data on the efficacy and safety of these agents, as well as their potential use, so that they are prepared to incorporate them into clinical practice as they become available.
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Medium/Method of Participation
This CME activity consists of a 0.75-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: November 26, 2019
Expiration Date: November 25, 2020
Estimated Time to Complete This Activity: 45 minutes
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William D. Tap, MD
Royalty: Companion Diagnostics
Receipt of intellectual property right/patent holder: Companion Diagnostics
Consulting fees/advisory boards: Blueprint Medicines, Daiichi Sankyo, Co., Ltd., Deciphera, Eli Lilly and Company, EMD Serono, Inc., Nanno Carrier
Ownership interest (stocks/stock options – excluding mutual funds): Atropos Therapeutics, Certis Oncology Solutions
The writer, peer reviewers, and activity planners have no financial relationships to disclose.
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This activity is supported by an educational grant from Daiichi Sankyo, Inc.
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