Sumanta K. Pal, MD
Clinical Professor, Department of Medical Oncology & Therapeutics Research
Co-Director, Kidney Cancer Program
City of Hope National Medical Center
Jaime Symowicz, PhD
Manager, Educational Strategy and Content
Rebecca L. Julian, MS, ELS
Senior Manager, Editorial
Samantha Gordon, MS
Director of CME
Kathryn Schaefer, MSN, RN, CPHRM
Associate Director, Education Quality and Compliance
East Lansing, MI
Haifa Kassis, MD
West Roxbury, MA
Upon completion, participants should be able to:
This activity is intended for oncologists, urologists, pathologists, surgeons, nurse practitioners, physician assistants, and nurses.
Statement of Need
Despite recent therapeutic advances, urothelial cancer (UC) remains difficult to treat and is associated with a poor prognosis. Platinum-based chemotherapy has been the cornerstone of first-line treatment in advanced disease, and immune checkpoint inhibitors have been shown to have activity in both the first-line and recurrent treatment settings. However, many patients do not respond to these therapies, and additional treatment options are limited. Among these patients, fibroblast growth factor receptor (FGFR) alterations have been identified as key oncogenic drivers, which has led to the development of novel selective FGFR tyrosine kinase inhibitors for the treatment of UC. Several FGFR inhibitors have been shown to achieve positive responses, and 1 treatment recently received FDA approval. Therefore, oncology clinicians need to recognize the clinical significance of FGFR aberrations and become familiar with current and emerging FGFR inhibitors to incorporate these therapies into clinical practice in a safe and appropriate manner as they become available.
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Medium/Method of Participation
This is a 0.5-credit CME/CE activity. To receive credit, read the introductory CME/CE material, complete all of the modules, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: December 22, 2020
Expiration Date: December 21, 2021
Estimated Time to Complete This Activity: 30 minutes
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Off-label/unapproved drug uses or products are mentioned within this activity.
The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
Sumanta K. Pal, MD
Consulting fees/advisory boards: Astellas Pharma US Inc., Aveo, Bristol-Myers Squibb, Eisai Inc., Exelixis, Inc., F. Hoffmann-La Roche Ltd., Genentech, Ipsen, Novartis Pharmaceuticals Corporation, Pfizer, Inc.
Haifa Kassis, MD, has indicated no real or apparent conflicts.
The peer reviewers and activity planners have no financial relationships to disclose.
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Acknowledgment of Commercial Support
This activity is supported by an educational grant from QED Therapeutics.
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