Targeted Therapy in Cholangiocarcinoma: Focus on FGFR Inhibitors
Milind Javle, MD
Professor, Department of Gastrointestinal Medical Oncology
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Chair, International Cholangiocarcinoma Research Network
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Rebecca L. Julian, MS, ELS
Senior Manager, Editorial
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Haifa Kassis, MD
West Roxbury, MA
Upon completion, participants should be able to:
- Use genetic testing to identify patients with cholangiocarcinoma who may benefit from FGFR inhibitors
- Apply emerging clinical data about FGFR inhibitors to individualize therapy for patients with cholangiocarcinoma
- Describe treatment-related adverse effects associated with FGFR inhibitors in patients with cholangiocarcinoma
This activity is intended for oncologists.
Statement of Need
Cholangiocarcinoma, a rare but often fatal malignancy, affects approximately 8,000 patients annually in the United States. Although surgery can be curative, up to 80% of patients are ineligible for surgical resection, and, consequently, survival is poor. Advances in technology and an increased understanding of the molecular pathways that drive oncogenesis has led to the development of novel therapies targeting FGFR fusions in cholangiocarcinoma. Oncologists need to be aware of the emerging clinical data on FGFR inhibitors and be prepared to integrate FGFR fusion testing as well as FGFR inhibitors into clinical practice in a safe and appropriate manner.
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Medium/Method of Participation
This CME activity consists of a 0.75-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: March 26, 2020
Expiration Date: March 25, 2021
Estimated Time to Complete This Activity: 45 minutes
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Milind Javle, MD
Consulting fees/advisory boards: Agios Pharmaceuticals, EMD Serono, Inc., Meclun, Merck & Co., Inc., QED Therapeutics
Fees received for promotional/non-CME activities: Lynx Group
The writer, peer reviewers, and activity planners have no financial relationships to disclose.
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This activity is supported by an educational grant from QED Therapeutics.
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