Decision Making in Advanced NSCLC: The Community Physician Perspective on Immunotherapy
NOTE: This activity was developed before the US FDA approval of the nivolumab plus ipilimumab combination in metastatic NSCLC in May 2020. Refer to the respective package inserts for more information.
Ioana Bonta, MD
Georgia Cancer Specialists
David Spigel, MD
Chief Scientific Officer
Director, Lung Cancer Research Program
Lori Pender, PharmD, MPH, BCOP
Manager, Educational Strategy and Content
Laura Rafferty, ELS
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Stephanie Wenick, MPhil
Wenick Communications, LLC
Chevy Chase, MD
Upon completion, participants should be able to:
- Describe the pros and cons of using PD-L1 expression and TMB as predictive biomarkers in advanced NSCLC
- Apply evidence from clinical trials, including molecular test results, when selecting treatment for patients with advanced NSCLC across lines of therapy
- Discuss methods to proactively identify and manage irAEs in at-risk patients with NSCLC
This activity is intended for medical oncologists, nurse practitioners, physician assistants, and other healthcare providers who treat and/or manage patients with lung cancer.
Statement of Need
The management of advanced NSCLC is becoming increasingly complex as a result of the rapid expansion of treatment options, nuances regarding biomarker-based clinical decision making, and the potential for irAEs with immunotherapy-based regimens. To optimize outcomes for these patients, it is critical that healthcare providers stay current in a rapidly evolving clinical landscape that requires them to order and interpret molecular tests, personalize treatment selection across lines of therapy, and anticipate and safely manage irAEs for their patients with advanced NSCLC.
Provided by Med-IQ.
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Med-IQ designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
Medium/Method of Participation
This CME activity consists of a 1.0-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: April 2, 2020
Expiration Date: April 1, 2021
Estimated Time to Complete This Activity: 1 hour
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The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
Ioana Bonta, MD
Consulting fees/advisory boards: Novartis Pharmaceuticals Corporation
David Spigel, MD, has indicated no real or apparent conflicts.
The writer, peer reviewers, and activity planners have no financial relationships to disclose.
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Acknowledgment of Commercial Support
This activity is supported by an educational grant from Bristol-Myers Squibb.
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