Decision Making in Advanced NSCLC: The Community Physician Perspective on Immunotherapy
NOTE: This activity was developed before the US FDA approvals of several new ICI regimens for the first-line treatment of advanced NSCLC, such as nivolumab plus ipilimumab (with and without 2 cycles of platinum-doublet chemotherapy) and atezolizumab monotherapy. Please refer to the respective package inserts for more information.
Ioana Bonta, MD
Georgia Cancer Specialists
David Spigel, MD
Chief Scientific Officer
Director, Lung Cancer Research Program
Lori Pender, PharmD, MPH, BCOP
Manager, Educational Strategy and Content
Laura Rafferty, ELS
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Stephanie Wenick, MPhil
Wenick Communications, LLC
Chevy Chase, MD
Upon completion, participants should be able to:
- Describe the pros and cons of using PD-L1 expression and TMB as predictive biomarkers in advanced NSCLC
- Apply evidence from clinical trials, including molecular test results, when selecting treatment for patients with advanced NSCLC across lines of therapy
- Discuss methods to proactively identify and manage irAEs in at-risk patients with NSCLC
This activity is intended for medical oncologists, nurse practitioners, physician assistants, and other healthcare providers who treat and/or manage patients with lung cancer.
Statement of Need
The management of advanced NSCLC is becoming increasingly complex as a result of the rapid expansion of treatment options, nuances regarding biomarker-based clinical decision making, and the potential for irAEs with immunotherapy-based regimens. To optimize outcomes for these patients, it is critical that healthcare providers stay current in a rapidly evolving clinical landscape that requires them to order and interpret molecular tests, personalize treatment selection across lines of therapy, and anticipate and safely manage irAEs for their patients with advanced NSCLC.
Provided by Med-IQ.
Med-IQ is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Med-IQ designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
Medium/Method of Participation
This CME activity consists of a 1.0-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: April 2, 2020
Expiration Date: April 1, 2021
Estimated Time to Complete This Activity: 1 hour
Med-IQ requires any person in a position to control the content of an educational activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines “relevant financial relationships” as those in any amount occurring within the past 12 months, including those of a spouse/life partner, that could create a conflict of interest (COI). Individuals who refuse to disclose will not be permitted to contribute to this CME activity in any way. Med-IQ has policies in place that will identify and resolve COIs prior to this educational activity. Med-IQ also requires faculty to disclose discussions of investigational products or unlabeled/unapproved uses of drugs or devices regulated by the US Food and Drug Administration.
The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
Ioana Bonta, MD
Consulting fees/advisory boards: Novartis Pharmaceuticals Corporation
David Spigel, MD, has indicated no real or apparent conflicts.
The writer, peer reviewers, and activity planners have no financial relationships to disclose.
Statement of Evidence-Based Content
Educational activities that assist physicians in carrying out their professional responsibilities more effectively and efficiently are consistent with the ACCME definition of continuing medical education (CME). As an ACCME-accredited provider of CME, it is the policy of Med-IQ to review and ensure that all the content and any recommendations, treatments, and manners of practicing medicine in CME activities are scientifically based, valid, and relevant to the practice of medicine. Med-IQ is responsible for validating the content of the CME activities it provides. Specifically, (1) all recommendations addressing the medical care of patients must be based on evidence that is scientifically sound and recognized as such within the profession; (2) all scientific research referred to, reported, or used in CME in support or justification of a patient care recommendation must conform to generally accepted standards of experimental design, data collection, and analysis.
Med-IQ is not liable for any decision made or action taken in reliance upon the information provided through this activity.
For questions or comments about this activity, please contact Med-IQ. Call (toll-free) 866 858 7434 or email email@example.com.
Operating system - Med-IQ supports the following operating systems:
- Microsoft Windows supported by Microsoft
- Mac OS supported by Apple
Browsers - Med-IQ supports the current version of each browser listed below, plus two prior versions:
Microsoft Internet Explorer
- Microsoft Edge
Operating system - Med-IQ supports the current operating system, plus two prior releases:
- Android (eg, Samsung Galaxy)
- Apple (eg, iPhone/iPad)
Browsers - Med-IQ supports the default browser for the applicable operating system release, plus two prior releases:
- Android (Chrome)
- Apple (Safari)
Applications & Software
PDF Viewer - Adobe Acrobat Reader or Adobe Reader
Adobe Flash Player - Med-IQ supports the current version, plus two prior versions
For technical assistance, please refer to our Support Manual.
The information provided through this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.
Privacy & Confidentiality
Med-IQ is committed to honoring your privacy and protecting any personal information you choose to share with us. For detailed information about our privacy notice, please visit: www.med-iq.com/privacy-statement/.
Acknowledgment of Commercial Support
This activity is supported by an educational grant from Bristol-Myers Squibb.
© 2020 Med-IQ, Inc.
Unless otherwise indicated, photographed subjects who appear within the content of this activity or on artwork associated with this activity are models; they are not actual patients or doctors.