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Clinical Advances in Diagnostics and Therapies for FGFR-Altered Cancer: June 2021 Updates: Part Three

Clinical Advances in Diagnostics and Therapies for FGFR-Altered Cancer: June 2021 Updates: Part Three

Webcast
Online Course | Specialties: Oncology
Released: 8/5/2021
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Expires: 8/4/2022
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Max Credits: 2.0
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Faculty
Sameek Roychowdhury, MD, PhD 
Associate Professor, Department of Internal Medicine 
Division of Medical Oncology 
Medical Director, CLIA Certified Cancer Genomics Laboratory 
The Ohio State University, James Cancer Hospital and Comprehensive Cancer Center
Columbus, OH

Antonio Iavarone, MD 
Professor  
Department of Neurology, Pathology  
Institute for Cancer Genetics  
Columbia University 
New York, NY 
 
Yohann Loriot, MD 
Medical Oncologist 
Gustave Roussy Cancer Institute  
Université Paris-Saclay   
Paris, France 

Activity Planners
Julie Blum, PhD
Director, Clinical Content
Med-IQ
Baltimore, MD

Samantha Gordon, MS
Accreditation Manager 
Med-IQ
Baltimore, MD

Amy Sison
Director of CME
Med-IQ
Baltimore, MD

Kathryn Schaefer, MSN, RN, CPHRM
Associate Director, Education Quality and Compliance
Med-IQ
East Lansing, MI 

Learning Objectives
Upon completion, participants should be able to:

  • Explain the rationale to therapeutically target the FGFR signaling pathway in cancer
  • Review recent and ongoing clinical trials for FGFR inhibitors with regard to biomarkers, mechanisms of action, efficacy, side effects, and safety
  • Discuss the future research and translational approaches on FGFR signaling from basic science to clinical studies

Target Audience
This activity is intended for oncology professionals including physicians, physician assistants, nurse practitioners, nurses, and researchers. 
 
Statement of Need
Advances with technology and an increased understanding of the molecular pathways that drive oncogenesis has led to the development of novel therapies targeting fibroblast growth factor receptor (FGFR) aberrations in multiple tumor types. Several of the FGFR inhibitors are producing profound and durable responses in cancer treatment. An FGFR inhibitor recently gained FDA approval in the treatment of urothelial cancer, and other approvals are anticipated. Optimizing the clinical use of FGFR inhibitors will depend on the appropriate selection of patients who are most likely to benefit from these agents as well as the selection of the optimal FGFR-targeting agent, taking into account the selectivity of the agents, efficacy and toxicity profiles, and the design and implementation of novel strategies to overcome resistance mechanisms and further improve response rates. To that end, developing a clear understanding of the emerging research and the evolving landscape of FGFR inhibitors in various tumor types is needed to effectively optimize the use these agents in clinical practice.

Providership Statement
Provided by Med-IQ. 
 
Accreditation/Designation Statements
Med-IQ is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Med-IQ designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Med-IQ is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.
 
This nursing activity has been approved for up to 2.0 contact hours.

Physician assistants and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available. 

Medium/Method of Participation
To receive credit, read the introductory CME/CE material, watch the webcast, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.  
 
Initial Release Date: August 5, 2021
Expiration Date: August 4, 2022
Estimated Time to Complete This Activity: 2 hours

Disclosure Policy
Med-IQ requires any person in a position to control the content of an educational activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines “relevant financial relationships” as those in any amount occurring within the past 24 months that could create a conflict of interest (COI). Individuals who refuse to disclose will not be permitted to contribute to this CME activity in any way. Med-IQ has policies in place that will identify and resolve COIs prior to this educational activity. Med-IQ also requires faculty to disclose discussions of investigational products or unlabeled/unapproved uses of drugs or devices regulated by the US Food and Drug Administration.

Off-label/unapproved drug uses or products are mentioned within this activity. 

Disclosure Statement
The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation. 
 
Antonio Iavarone, MD 
Receipt of intellectual property right/patent holder: QIAGEN
Consulting fees/advisory boards: AIMEBIO Inc.
Contracted Research: AstraZeneca, Taiho Pharmaceutical Group
 
Yohann Loriot, MD 
Consulting fees/advisory boards: Astellas, AstraZeneca, Bristol-Myers Squibb, Immunomedics, Janssen, Merck & Co., Inc., MSD, Pfizer, Inc., Seattle Genetics, Taiho Pharmaceutical Group
 
Sameek Roychowdhury, MD, PhD
Consulting fees/advisory boards: Incyte Corporation, Merck & Co., Inc.

The peer reviewers and activity planners have no financial relationships to disclose. 
  
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Educational activities that assist physicians in carrying out their professional responsibilities more effectively and efficiently are consistent with the ACCME definition of continuing medical education (CME). As an ACCME-accredited provider of CME, Med-IQ has a policy to review and ensure that all the content and any recommendations, treatments, and manners of practicing medicine in CME activities are scientifically based, valid, and relevant to the practice of medicine. Med-IQ is responsible for validating the content of the CME activities it provides. Specifically, (1) all recommendations addressing the medical care of patients must be based on evidence that is scientifically sound and recognized as such within the profession; (2) all scientific research referred to, reported, or used in CME in support or justification of a patient care recommendation must conform to generally accepted standards of experimental design, data collection, and analysis. 
 
Med-IQ is not liable for any decision made or action taken in reliance upon the information provided through this activity. 
 
Contact Information        
For questions or comments about this activity, please contact Med-IQ. Call (toll-free) 866 858 7434 or email info@med-iq.com.

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Disclaimer
The information provided through this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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This activity is available free of charge to participants.

Acknowledgement of Commercial Support
This activity is supported by an educational grant from QED Therapeutics.

Copyright
Copyrighted
Abstract
  • In contrast to oncogene aberrations in lung cancer (EGFR, ALK), there are no clear specific clinical patterns associated with FGFR alterations in urothelial cancer
  • It is not yet clear whether FGFR status can be used to predict response to immune checkpoint inhibitor chemotherapy
  • Inhibitors of oxidative phosphorylation have been introduced in clinical trials to treat FGFR3-TACC3 fusion-positive tumors
  • FGFR3-TACC3 fusions are among the most powerful predictors of clinical response to FGFR inhibitor
  • The FGFR3-TACC3 fusion induces sensitivity to inhibitors of mitochondrial metabolism in glioblastoma

 
References
Necchi A, Raggi D, Volpi CC, Giannatempo P, Colecchia M, Gloghini A. Comparison of fibroblast growth-factor receptor gene alterations at the DNA versus messenger RNA level in advanced urothelial cancer: insights for clinical research. Eur Urol Focus. 2019;5(4):689-692.

Msaouel P, Siefker-Radtke AO, Sweis R, et al. Sitravatinib (sitra) in combination with nivolumab (nivo) demonstrates clinical activity in checkpoint inhibitor (CPI) naïve, platinum-experienced patients (pts) with advanced or metastatic urothelial carcinoma (UC). Ann Oncol. 2020;31(suppl_4):S550-S550.

Frattini V, Pagnotta SM, Tala, et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018;553(7687):222-227.

Voss MH, Hierro C, Heist RS, et al. A phase i, open-label, multicenter, dose-escalation study of the oral selective FGFR inhibitor Debio 1347 in patients with advanced solid tumors harboring FGFR gene alterations. Clin Cancer Res. 2019;25(9):2699-2707.

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