The Frontline Treatment of Peripheral T-Cell Lymphoma: Current and Future Strategies
Which of the following peripheral T-cell lymphoma (PTCL) subtypes is associated with more favorable outcomes?
A. Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL)
B. ALK-negative ALCL
C. PTCL-not otherwise specified
D. Angioimmunoblastic T-cell lymphoma
A.) ALK-positive ALCL is associated with more favorable outcomes. Learn more about the PTCL subtypes by viewing the modules.
Ref: Schmitz N, et al. Blood. 2010;116:3418-25.
Please choose a module from the options below. To receive credit and a certificate, you must complete all of the modules in this activity.
Welcome to this Med-IQ Select on peripheral T-cell lymphoma (PTCL). Med-IQ Select is a unique online educational offering that allows you to pick and choose the content you'd like to view--in any order and at your convenience.
To get started, click "view" on any of the modules below. To receive credit and a certificate, you must complete all of the modules.
Time to Complete: 11 minutes
Time to Complete: 7 minutes
Time to Complete: 12 minutes
Complete all of the above modules to earn credit;
0 out of 3 modules complete
Steven Horwitz, MD
Department of Medicine
Memorial Sloan Kettering Cancer Center
New York, NY
Christie Avraamides, PhD
Clinical Content Manager
Rebecca L. Julian, MS, ELS
Senior Manager, Editorial
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Edward Allan Racela Sison, MD
Missouri City, TX
Upon completion, participants should be able to:
- Incorporate clinical evidence on the benefits and limitations of available therapeutic regimens into individualized treatment decisions for patients with newly diagnosed PTCL, including those whose tumors express CD30
- Discuss the clinical evidence regarding emerging therapeutic strategies in treatment-naïve PTCL
This activity is intended for hematologist-oncologists and other healthcare professionals involved in making treatment decisions for patients with PTCL.
Statement of Need
PTCL accounts for 15% of non-Hodgkin lymphoma cases. Traditionally, its treatment has reflected that of B-cell lymphoma; however, this treatment paradigm is associated with high relapse rates. Fortunately, a novel targeted therapy is now available for patients with treatment-naïve PTCL whose tumors express CD30. Therefore, hematology/oncology professionals need to have a good working knowledge of the clinical evidence on the safety and efficacy of this novel therapy and understand the clinical significance of CD30 expression to best care for their patients with CD30-positive PTCL. In addition, there is an active research pipeline investigating the utility of novel therapeutic strategies in newly diagnosed PTCL, and clinicians need to have a solid understanding of the efficacy and toxicity outcomes associated with these novel treatments to enable the individualized and appropriate use of these agents in clinical practice as they become available.
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Medium/Method of Participation
This CME activity consists of a 0.5-credit online publication. To receive credit, read the introductory CME material, complete all of the modules, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: August 2, 2019
Expiration Date: August 1, 2020
Estimated Time to Complete This Activity: 30 minutes
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Steven Horwitz, MD
Consulting fees/advisory boards: ADC Therapeutics, Affimed, Aileron Therapeutics, Angimmune, BeiGene, Corvus Pharmaceuticals, Forty Seven, Infinity Pharmaceuticals/Verastem, Innate Pharma, Kura Oncology, Kyowa Hakka Kirin, Merck & Co., Inc., Millennium: The Takeda Oncology Company, miRagen Therapeutics, Mundipharma, Portola Pharmaceuticals, Seattle Genetics, Syros Pharmaceuticals
Contracted research: ADC Therapeutics, Aileron Therapeutics, Celgene Corporation, Forty Seven, Infinity Pharmaceuticals/Verastem, Kyowa Hakka Kirin, Millennium: The Takeda Oncology Company, Seattle Genetics, Trillium Therapeutics
Edward Allan Racela Sison, MD
Salary: Covance, Inc.
Ownership interest (stocks/stock options – excluding mutual funds): Laboratory Corporation of America, United Health Group Inc.
The peer reviewers and other activity planners have no financial relationships to disclose.
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