Farrukh T. Awan, MD, MS
Associate Professor of Internal Medicine
Division of Hematology
The Ohio State University Comprehensive Cancer Center
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Laura Rafferty, ELS
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
Lead Nurse Planner
East Lansing, MI
Upon completion, participants should be able to:
- Implement evidence-based prophylaxis algorithms to mitigate the risk of TLS in patients undergoing potent anticancer therapy
This activity is intended for hematologist/oncologists and medical oncologists.
Statement of Need
The consequences of rapid cancer cell lysis observed as a result of certain treatments for several hematologic malignancies and select solid tumors—known as tumor lysis syndrome (TLS)—can result in serious complications and even death without aggressive preventive and management measures. With the continuous improvement in the armamentarium of available anticancer therapies, this metabolic emergency is increasingly observed in patients with malignancies not historically considered to be high risk, including chronic lymphocytic leukemia (CLL). However, guidelines for preventing and managing TLS in high-risk patients with CLL are based largely on expert consensus. Hematologist/oncologists and medical oncologists must therefore become skilled in the identification of patients with underappreciated TLS risk and proper techniques to prevent and manage this potentially fatal complication.
Provided by Med-IQ.
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Med-IQ designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Medium/Method of Participation
This CME activity consists of a 0.25-credit publication. To receive credit, read the introductory CME material, read the publication, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: June 15, 2018
Expiration Date: June 14, 2019
Estimated Time to Complete This Activity: 15 minutes
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The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
Farrukh T. Awan, MD, MS
Consulting fees/advisory boards: AbbVie Inc., Gilead Sciences, Inc., Janssen Pharmaceuticals, Inc., Pharmacyclics LLC
Contracted research: Pharmacyclics LLC
The peer reviewers and activity planners have no financial relationships to disclose.
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