Rebecca A. Previs, MD
Assistant Professor of Obstetrics and Gynecology
Division of Gynecologic Oncology
Duke University Medical Center
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Rebecca Julian, MS, ELS
Senior Manager, Editorial
Samantha Gordon, MS
Director of CME
Upon completion, participants should be able to:
This activity is intended for primary care providers, gynecologists, and advanced practice providers in women’s health.
Statement of Need
Lynch syndrome, also known historically as hereditary nonpolyposis colorectal cancer (HNPCC), is an underdiagnosed condition that increases the risk of gynecologic, gastrointestinal, and other cancers. Lynch syndrome accounts for 2% to 3% of all colorectal cancers in the United States, and the estimated prevalence is 1 in about 400 in the general population. People with the syndrome are estimated to have a 40% to 80% lifetime cumulative risk of colorectal cancer. In addition, women with Lynch syndrome have a 50% percent higher risk of uterine cancers and a 4- to 5-fold increased risk of ovarian cancer. Notably, people with Lynch syndrome are usually diagnosed with cancer at younger ages, often in their 30s and 40s.
Lynch syndrome is caused by inherited mutations affecting any of 4 DNA mismatch repair (MMR) genes, MSH2, MLH1, PMS2, or MSH6, or by a deletion in the epithelial cellular adhesion molecule (EPCAM) gene. Diagnosing Lynch syndrome requires direct germline testing, but microsatellite instability testing and immunohistochemical analyses can be used for screening. Clinicians need to be aware of Lynch syndrome and understand how to diagnose it to effectively manage patients with this condition.
This activity was developed by Med-IQ in collaboration with Duke Health.
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Med-IQ designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
Medium/Method of Participation
This CME/CE activity consists of a 0.25-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the post-survey, evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: January 26, 2021
Expiration Date: January 25, 2022
Estimated Time to Complete This Activity: 15 minutes
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The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
Rebecca A. Previs, MD
Consulting fees/advisory boards: Myriad Genetics
The peer reviewers and activity planners have no financial relationships to disclose.
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