Medical Insiders: Evolving Evidence for the Role of SGLT Inhibition in Type 1 Diabetes Management
Although this class of noninsulin agents is not yet approved for use in T1DM, 53% of surveyed endocrinologists and endocrinology-focused advanced practice professionals have prescribed it as adjunctive therapy for their patients with this condition.
Although SGLT inhibitors are not yet approved for use in T1DM, 53% of surveyed endocrinologists and endocrinology-focused advanced practice professionals have prescribed them as adjunctive therapy for their patients with this condition.
John B. Buse, MD, PhD - Chair
Verne S. Caviness Distinguished Professor
Chief, Division of Endocrinology
Director, Diabetes Center
Director, NC Translational and Clinical Sciences Institute
Executive Associate Dean, Clinical Research
University of North Carolina School of Medicine
Chapel Hill, NC
Thomas Lynch O’Connell, MD, FACE
Endocrinology, Diabetes and Metabolism Division
Duke Health, Kernodle Clinic
Wendy S. Lane, MD
Mountain Diabetes & Endocrine Center
Erin Grothey, MS
Clinical Content Manager
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Upon completion, participants should be able to:
- Recognize the rationale for using SGLT1 and SGLT2 inhibitors for the management of hyperglycemia in patients with T1DM
- Evaluate the safety and efficacy data regarding the use of SGLT inhibitors in combination with insulin for the management of T1DM
This activity is intended for endocrinologists and endocrinology-focused nurse practitioners and physician assistants.
Statement of Need
Despite critical advances in insulin formulations, delivery methods, and monitoring approaches, control of hyperglycemia in patients with type 1 diabetes mellitus (T1DM) remains suboptimal. In an effort to minimize the risk of severe hypoglycemia or obesity, these patients often choose to maintain a degree of hyperglycemia, which in turn puts them at risk of developing related complications. Providers are increasingly exploring the possibility of prescribing add-on therapy to existing insulin treatment in patients with T1DM. Although sodium-glucose cotransporter (SGLT) 2 inhibitors have been approved for use in patients with type 2 diabetes mellitus for some time, the use of this drug class in patients with T1DM is currently off-label. Endocrinologists and endocrinology-focused advanced care practitioners would benefit from expert insight regarding results of recent phase 3 clinical trials investigating the use of SGLT2 and SGLT1/2 inhibitors in this patient population, as well as guidance about how to discuss with patients the benefits and potential harms of SGLT inhibition.
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Med-IQ designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurses, nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
Instructions to Receive Credit
To receive credit, read the introductory CME material, watch the webcast, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: November 30, 2018
Expiration Date: November 29, 2019
Estimated Time to Complete This Activity: 45 minutes
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The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation.
John B. Buse, MD, PhD
Contracted research: Neurimmune
Ownership interest (stocks/stock options – excluding mutual funds): Mellitus Health, PhaseBio Pharmaceuticals, Inc.
Thomas Lynch O’Connell, MD, FACE
Fees received for promotional/non-CME activities: AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Novo Nordisk, Sanofi-aventis U.S. Inc.
Wendy S. Lane, MD
Consulting fees/advisory boards: Insulet Corporation, Novo Nordisk, Sanofi-aventis U.S. Inc.
Contracted research: Dexcom, Inc., Novo Nordisk, Sanofi-aventis U.S. Inc.
Other (speakers bureau): Dexcom, Inc., Insulet Corporation, Novo Nordisk
The peer reviewers and activity planners have no financial relationships to disclose.
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This activity is supported by an educational grant from Sanofi US and Lexicon Pharmaceuticals, Inc.
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