This activity was developed in collaboration with Cleveland Clinic Foundation Center for Continuing Education and
D. Progressive ASCVD
Patients with hyperlipidemia and progressive ASCVD would most benefit from the addition of PCSK9 inhibitors to statins as secondary preventive therapy. (Jellinger PS, et al. Endoc Pract. 2017;23:1-87.)
Leslie Cho, MD
Section Head, Preventive Cardiology and Rehabilitation
Director, Women’s Cardiovascular Center
Steven Nissen, MD
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Chairman, Robert and Suzanne Tomsich Department of Cardiovascular Medicine
Katherine J. Hoercher, RN, FAHA
Heart and Vascular Institute
Erin Grothey, MS
Clinical Content Manager
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Upon completion, participants should be able to:
- Describe clinical trial data for PCSK9 inhibitor therapeutics
- Compare guideline recommendations when choosing which patients should receive PCSK9 inhibitors
- Discuss the patient groups that would most benefit from PCSK9 inhibitor therapy
This activity is intended for cardiologists, endocrinologists, primary care physicians, physician assistants, advanced practice nurses, pharmacists, and other healthcare professionals involved in the care of patients with elevated cholesterol levels.
Statement of Need
The first PCSK9 inhibitors were approved in the summer of 2015, creating a significant change in the treatment landscape for patients with dyslipidemia. Identifying at-risk patients who are candidates for this treatment, as well as understanding when and how to initiate it, remains complex because of the wealth of clinical data and varying practice recommendations from multiple professional associations. It is important that healthcare providers receive updates on the current management of dyslipidemia to achieve optimal outcomes in this patient population. Although recent prospective data support the clinical utility of PCSK9 inhibitors, many important unanswered questions remain related to the implications of long-term use and approaches for identifying optimal candidates for treatment.
This activity was developed in collaboration with Cleveland Clinic Foundation Center for Continuing Education and Med-IQ.
The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.
Med-IQ is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 0.5 contact hour (0.05 CEUs) of credit for pharmacists. ACPE #0476-0000-18-003-H01-P. This knowledge-based activity is designed for all pharmacists.
Nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
Instructions to Receive Credit
To receive credit, read the introductory CME/CPE material, listen to the audiocast, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: July 17, 2018
Expiration Date: July 16, 2019
Estimated Time to Complete This Activity: 30 minutes
In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.
Leslie Cho, MD
Consulting fees/advisory boards: Amgen
Contracted research: Amgen, Esperion, Sanofi-aventis U.S. Inc.
Katherine J. Hoercher, RN, FAHA, has indicated no real or apparent conflicts.
Steven Nissen, MD, has indicated no real or apparent conflicts.
The peer reviewers and activity planners have no financial relationships to disclose.
For questions or comments about this activity or CPE contact hours, please contact Med-IQ. Call (toll-free) 866 858 7434 or email firstname.lastname@example.org.
To contact the CME provider, call 216-444-9990.
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The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.
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Acknowledgment of Commercial Support
This activity is supported by an educational grant from Amgen.
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Unless otherwise indicated, photographed subjects who appear within the content of this activity or on artwork associated with this activity are models; they are not actual patients or doctors.