Modulating JAK Signaling in IBD
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Welcome to this Med-IQ Select on the role of Janus kinase (JAK) signaling in inflammatory bowel disease (IBD). Med-IQ Select is a unique online educational offering that allows you to pick and choose the content you'd like to view—in any order and at your convenience.
To get started, click "view" on any of the modules below. To receive credit and a certificate, you must complete all of the modules.
Time to complete: 7 minutes
Whiteboard Animation Video
Time to complete: 2 minutes
Whiteboard Animation Video
Time to complete: 2 minutes
Time to complete: 15 minutes
Time to complete: 10 minutes
Complete all of the above modules to earn credit;
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Benjamin L. Cohen, MD, MAS
Assistant Professor, Dr. Henry D. Janowitz Division of Gastroenterology
Icahn School of Medicine at Mount Sinai
New York, NY
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Kathryn Schaefer, MSN, RN, CPHRM
Senior Manager, Accreditation and Compliance
East Lansing, MI
Upon completion, participants should be able to:
- Describe the clinical rationale for targeting JAK signaling in the treatment of IBD
- Incorporate clinical evidence on the safety and efficacy of JAK inhibitors into current and future treatment decisions for patients with UC and CD
This activity is intended for gastroenterologists.
Statement of Need
IBD, which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, lifelong condition that requires continuous management. More than 1 million people in the United States are living with IBD, and as many as 70,000 new cases are diagnosed each year. The incidence of IBD is highest among patients who are in their 20s to 40s, which is one of the most productive periods of life. Indeed, IBD has a substantial impact on patient quality of life and negatively affects school, work, and social situations. Although the exact cause of IBD is not known, the disease appears to be the result of an interaction between the immune system, environmental factors, and genetic predisposition.
There is currently no cure for either UC or CD, and patients require long-term medical therapy. Over the past decade, TNF-alpha and integrin inhibitors have emerged as a mainstay for managing those who fail to respond to conventional treatments. However, a substantial proportion of patients will experience primary non-response or secondary loss of response to these agents, prompting the need for additional therapeutic options with distinct mechanisms of action.
Current strategies have mainly focused on modulating extracellular proinflammatory cytokines, but more recent investigation has shifted focus to intracellular transducers of these signals. The JAK family has emerged as a leading target; of the more than 200 known cytokines, approximately 60 of them use the JAK pathway to communicate signals inside the cell. Because it is unclear which specific cytokines are responsible for driving the progression of various autoimmune diseases, including IBD, targeting the JAK family is a rational therapeutic approach with potentially broad applications.
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Med-IQ designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Medium/Method of Participation
This is a 0.75-credit CME activity. To receive credit, read the introductory CME material, complete all of the modules, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
Initial Release Date: August 30, 2019
Expiration Date: August 29, 2020
Estimated Time to Complete This Activity: 45 minutes
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Benjamin L. Cohen, MD, MAS
Consulting fees/advisory boards: AbbVie Inc., Alfasigma USA, Inc., Celltrion, Grifols, Sublimity Therapeutics
Other (expert witness): Allergan
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